High-Protein Spinach and Artichoke Chicken Casserole: An Incredible Ultimate Meal
If you’re looking for a dish that’s both delicious and packed with protein, then this High-Protein Spinach and Artichoke Chicken Casserole: An Incredible Ultimate Meal is just what you need! This recipe has been a beloved staple in my home, especially on busy weeknights or when we have family gatherings. It’s comforting, creamy, and bursting with flavor, making it a hit with both kids and adults alike.
I love how easy it is to whip up this casserole. With simple ingredients that you probably already have at home, you’ll find yourself making it again and again. Plus, it’s versatile enough to fit into any meal plan — whether you’re serving it for dinner or as a hearty lunch!
Why You’ll Love This Recipe
- Quick to prepare: With just 15 minutes of prep time, this casserole comes together effortlessly.
- Family-friendly: The creamy texture and cheesy goodness make it a favorite for everyone at the table.
- High in protein: Packed with chicken and Greek yogurt, this dish helps you stay full and satisfied.
- Make-ahead friendly: You can easily prepare it in advance and pop it in the oven when you’re ready to eat.
- Delicious leftovers: This casserole tastes even better the next day, making great lunch options!

Ingredients You’ll Need
To create this amazing High-Protein Spinach and Artichoke Chicken Casserole: An Incredible Ultimate Meal, you’ll need some simple and wholesome ingredients. Here’s what you’ll gather:
For the Casserole
- 2 cups cooked, shredded chicken (or rotisserie chicken)
- 1 cup chopped fresh spinach (or thawed frozen spinach)
- 1 cup canned artichoke hearts, drained and chopped
- 1 cup Greek yogurt (or sour cream)
- 1 cup shredded mozzarella cheese
- ½ cup grated Parmesan cheese
- 3 cloves garlic, minced
- 1 tablespoon olive oil
- 1 teaspoon dried oregano
- 1 teaspoon onion powder
- 1 teaspoon salt
- ½ teaspoon black pepper
- 1 cup breadcrumbs (optional, for topping)
Variations
One of the best things about this casserole is its flexibility! You can easily tweak the ingredients based on your preferences or what you have on hand.
- Swap the protein: Use turkey or shredded tofu instead of chicken for a different flavor profile.
- Go dairy-free: Substitute Greek yogurt with a plant-based yogurt and use dairy-free cheese alternatives.
- Add more veggies: Toss in some diced bell peppers or mushrooms for extra nutrients and flavor.
- Change up the spices: Experiment with your favorite herbs like thyme or basil to give it a unique twist.
How to Make High-Protein Spinach and Artichoke Chicken Casserole: An Incredible Ultimate Meal
Step 1: Preheat the Oven
Preheat your oven to 350°F (175°C). This step is crucial because it ensures your casserole cooks evenly from the start.
Step 2: Sauté Spinach
In a skillet over medium heat, add olive oil followed by minced garlic. Sauté until fragrant before adding chopped spinach. Cook until it’s wilted and vibrant. This process enhances the flavors while making sure the spinach retains its bright color.
Step 3: Combine Ingredients
In a large bowl, mix together your cooked chicken, sautéed spinach, artichoke hearts, Greek yogurt, mozzarella cheese, Parmesan cheese, oregano, onion powder, salt, and black pepper. Stir well until everything is fully combined. This step is where all those delicious flavors meld together!
Step 4: Prepare for Baking
Grease your baking dish with cooking spray or olive oil to prevent sticking. Then pour in your mixture from the bowl, spreading it out evenly. If you love a crunchy topping, sprinkle breadcrumbs over the top now!
Step 5: Bake to Perfection
Place your casserole in the preheated oven and bake for about 30-35 minutes. You’ll know it’s done when the top is golden brown and bubbly around the edges. This makes all those flavors come alive!
Step 6: Cool Before Serving
Once baked, allow your casserole to cool for a few minutes before serving. This helps set up the dish so it’s easier to serve while still being delightfully warm.
And there you have it! A cozy High-Protein Spinach and Artichoke Chicken Casserole that’s sure to impress anyone who takes a bite! Enjoy!
Pro Tips for Making High-Protein Spinach and Artichoke Chicken Casserole: An Incredible Ultimate Meal
Making this delightful casserole is not only easy but also rewarding! Here are some pro tips to ensure your dish turns out perfectly every time:
-
Use fresh ingredients: Opting for fresh spinach and high-quality artichoke hearts enhances the flavor and nutritional value of your casserole, making it even more satisfying.
-
Mix in extra veggies: Feel free to sneak in additional vegetables like bell peppers or mushrooms. This not only boosts the fiber content but also adds vibrant colors and flavors to your meal.
-
Adjust cheese types: If you’re a fan of different cheeses, try substituting mozzarella with provolone or gouda for a unique twist on the classic flavor profile.
-
Make it ahead of time: You can prepare the casserole a day in advance and store it in the refrigerator. Just pop it into the oven before serving—perfect for busy weeknights!
-
Check for doneness: To ensure your casserole is fully cooked, use a food thermometer. The internal temperature should reach 165°F (74°C) for optimal safety and quality.
How to Serve High-Protein Spinach and Artichoke Chicken Casserole: An Incredible Ultimate Meal
When it comes to serving this delicious casserole, presentation is key! Here are some ideas to elevate your dining experience:
Garnishes
- Fresh basil or parsley: A sprinkle of fresh herbs not only adds color but also brings a burst of freshness that complements the rich flavors of the casserole.
- Lemon wedges: Serving lemon wedges on the side allows everyone to add a splash of citrus that brightens up every bite.
Side Dishes
- Steamed broccoli: This simple side dish is nutritious and adds a nice crunch, balancing out the creamy texture of the casserole.
- Quinoa salad: A light quinoa salad with cherry tomatoes, cucumber, and a zesty lemon dressing pairs beautifully with the richness of the casserole while boosting protein content.
- Mixed green salad: A refreshing salad with mixed greens, avocado, and vinaigrette provides a crisp contrast to the warm, hearty casserole.
- Garlic bread: Crispy garlic bread is perfect for scooping up those cheesy bites; it’s an indulgent yet satisfying accompaniment that everyone loves!
With these serving suggestions and tips, your High-Protein Spinach and Artichoke Chicken Casserole will be an incredible meal that impresses family and friends alike! Enjoy every delicious bite!

Make Ahead and Storage
This High-Protein Spinach and Artichoke Chicken Casserole is perfect for meal prep! With its hearty ingredients and delicious flavors, you can easily prepare it in advance and enjoy it throughout the week.
Storing Leftovers
- Store any leftovers in an airtight container in the refrigerator.
- Enjoy within 3-4 days for the best taste and freshness.
Freezing
- Allow the casserole to cool completely before freezing.
- Wrap it tightly with plastic wrap or foil, or place it in a freezer-safe container.
- It can be frozen for up to 2 months. Label with the date for easy tracking.
Reheating
- Thaw overnight in the refrigerator if frozen.
- Reheat individual portions in the microwave, or reheat the entire casserole in a preheated oven at 350°F (175°C) until warmed through, about 20-25 minutes.
FAQs
Here are some common questions you might have about this delightful recipe!
Can I make High-Protein Spinach and Artichoke Chicken Casserole ahead of time?
Absolutely! This casserole is ideal for making ahead. Just follow the storage instructions above to keep your dish fresh and ready to enjoy later.
What can I substitute for chicken in High-Protein Spinach and Artichoke Chicken Casserole?
If you’re looking for alternatives, shredded turkey or cooked quinoa can work beautifully as a protein source instead of chicken.
Is there a vegetarian option for High-Protein Spinach and Artichoke Chicken Casserole?
Yes! You can replace chicken with chickpeas or a plant-based protein. Just ensure to adjust cooking times accordingly if using raw ingredients.
How do I know when my casserole is done baking?
The casserole is ready when the top is golden brown and bubbling around the edges. A food thermometer should read at least 165°F (74°C) when it’s fully cooked.
Can I add more vegetables to this casserole?
Definitely! Feel free to add vegetables like bell peppers, zucchini, or mushrooms to enhance flavor and nutrition.
Final Thoughts
I hope you enjoy making this High-Protein Spinach and Artichoke Chicken Casserole as much as I do! It’s not only packed with flavor but also offers a nourishing meal that’s simple to prepare. Whether you’re feeding a family or just yourself, this recipe is sure to become a favorite. Happy cooking, and don’t forget to share your experience with me!
High-Protein Spinach and Artichoke Chicken Casserole
If you’re in need of a comforting and nutritious meal, look no further than this High-Protein Spinach and Artichoke Chicken Casserole. Packed with tender chicken, vibrant spinach, and creamy ingredients, this dish is not only delicious but also high in protein, making it perfect for family gatherings or busy weeknights. The combination of Greek yogurt and cheese creates a rich texture that pleases both kids and adults alike. Plus, it’s easy to prepare and can be made ahead of time, ensuring you have a satisfying meal ready to go whenever hunger strikes. Serve it warm with a side salad for a balanced dinner everyone will love!
- Prep Time: 15 minutes
- Cook Time: 35 minutes
- Total Time: 50 minutes
- Yield: Serves 8
- Category: Main
- Method: Baking
- Cuisine: American
Ingredients
- 2 cups cooked, shredded chicken
- 1 cup chopped fresh spinach
- 1 cup canned artichoke hearts
- 1 cup Greek yogurt
- 1 cup shredded mozzarella cheese
- ½ cup grated Parmesan cheese
- 3 cloves garlic
- 1 tablespoon olive oil
- 1 teaspoon dried oregano
- 1 teaspoon onion powder
- 1 teaspoon salt
- ½ teaspoon black pepper
- 1 cup breadcrumbs (optional)
Instructions
- Preheat the oven to 350°F (175°C).
- In a skillet, heat olive oil over medium heat; add minced garlic and sauté until fragrant. Stir in chopped spinach and cook until wilted.
- In a large bowl, combine cooked chicken, sautéed spinach, chopped artichokes, Greek yogurt, mozzarella cheese, Parmesan cheese, oregano, onion powder, salt, and black pepper. Mix well.
- Grease a baking dish and spread the mixture evenly; top with breadcrumbs if desired.
- Bake for 30-35 minutes until golden brown and bubbly.
- Allow to cool slightly before serving.
Nutrition
- Serving Size: 1/8 of the casserole (approximately 150g)
- Calories: 280
- Sugar: 3g
- Sodium: 450mg
- Fat: 12g
- Saturated Fat: 5g
- Unsaturated Fat: 6g
- Trans Fat: 0g
- Carbohydrates: 18g
- Fiber: 2g
- Protein: 25g
- Cholesterol: 70mg